Bioactivation and reactivity research advances - 2024 year in review.

IF 3.4 2区医学 Q2 PHARMACOLOGY & PHARMACY

Drug Metabolism Reviews Pub Date : 2025-07-11 DOI:10.1080/03602532.2025.2530407

Joyce Liu, Upendra A Argikar, Pietro Brunetti, Maria Chatzopoulou, Luying Chen, Sungjoon Cho, Simon Hauri, Valerie Kramlinger, Jakob Lang, Bin Ma, Karoline Rehm, Herana Kamal Seneviratne, Lloyd Wei Tat Tang, John C Tran, Guo Zhong, S Cyrus Khojasteh

引用次数: 0

Abstract

Bioactivation continues to be an important aspect of compound evaluation during drug discovery and development, as understanding the metabolic pathways that can lead to the formation of reactive metabolites can facilitate the design of safer drugs. This year's review on bioactivation and reactivity features 17 articles that reflect the latest advances and findings in this research area. This collection of articles is organized into 3 general themes: (1) mechanisms of bioactivation and the impact of bioactivation on safety, (2) new assays for assessing reactive metabolite formation, and (3) computational approaches for predicting reactive metabolite formation.

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生物活性和反应性研究进展- 2024年综述。

在药物发现和开发过程中，生物活化仍然是化合物评估的一个重要方面，因为了解导致反应性代谢物形成的代谢途径可以促进设计更安全的药物。今年的《生物活性和反应性评论》有17篇文章，反映了这一研究领域的最新进展和发现。这些文章分为三个主题：(1)生物活化的机制和生物活化对安全性的影响；(2)评估反应性代谢物形成的新方法；(3)预测反应性代谢物形成的计算方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Metabolism Reviews 医学-药学

CiteScore

11.10

自引率

1.70%

发文量

审稿时长

1 months

期刊介绍： Drug Metabolism Reviews consistently provides critically needed reviews of an impressive array of drug metabolism research-covering established, new, and potential drugs; environmentally toxic chemicals; absorption; metabolism and excretion; and enzymology of all living species. Additionally, the journal offers new hypotheses of interest to diverse groups of medical professionals including pharmacologists, toxicologists, chemists, microbiologists, pharmacokineticists, immunologists, mass spectroscopists, as well as enzymologists working in xenobiotic biotransformation.