A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-07-11 DOI:10.1038/s41556-025-01680-3

引用次数: 0

Abstract

BLTP2 is a bridge-like lipid transport protein that operates at contacts between the endoplasmic reticulum and the plasma membrane. We show that phosphatidylethanolamine is transported to the plasma membrane by BLTP2, where it maintains membrane fluidity. Depletion of BLTP2 significantly impaired the metastasis of a triple-negative breast cancer cell line in xenografts.

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桥状脂质转运蛋白控制质膜脂质的组成和流动性

BLTP2是一种桥状脂质转运蛋白，在内质网和质膜之间的接触处起作用。我们发现磷脂酰乙醇胺通过BLTP2转运到质膜，在那里它维持膜的流动性。BLTP2的缺失显著损害了三阴性乳腺癌细胞系在异种移植物中的转移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology