{"title":"A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity","authors":"","doi":"10.1038/s41556-025-01680-3","DOIUrl":null,"url":null,"abstract":"BLTP2 is a bridge-like lipid transport protein that operates at contacts between the endoplasmic reticulum and the plasma membrane. We show that phosphatidylethanolamine is transported to the plasma membrane by BLTP2, where it maintains membrane fluidity. Depletion of BLTP2 significantly impaired the metastasis of a triple-negative breast cancer cell line in xenografts.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"93 1","pages":""},"PeriodicalIF":19.1000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41556-025-01680-3","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
BLTP2 is a bridge-like lipid transport protein that operates at contacts between the endoplasmic reticulum and the plasma membrane. We show that phosphatidylethanolamine is transported to the plasma membrane by BLTP2, where it maintains membrane fluidity. Depletion of BLTP2 significantly impaired the metastasis of a triple-negative breast cancer cell line in xenografts.
期刊介绍:
Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to:
-Autophagy
-Cancer biology
-Cell adhesion and migration
-Cell cycle and growth
-Cell death
-Chromatin and epigenetics
-Cytoskeletal dynamics
-Developmental biology
-DNA replication and repair
-Mechanisms of human disease
-Mechanobiology
-Membrane traffic and dynamics
-Metabolism
-Nuclear organization and dynamics
-Organelle biology
-Proteolysis and quality control
-RNA biology
-Signal transduction
-Stem cell biology