{"title":"V-ATPase assembly at leaky lysosomes","authors":"Alf Håkon Lystad","doi":"10.1038/s41594-025-01612-7","DOIUrl":null,"url":null,"abstract":"Sudden loss of lysosomal acidity triggers a rapid response. Two studies now identify the metazoan RAVE (mRAVE) complex as essential for V-ATPase reassembly and activation under such conditions; map interactions between mRAVE and V-ATPase; and identify a link to CASM, a non-canonical autophagy pathway.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"192 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01612-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Sudden loss of lysosomal acidity triggers a rapid response. Two studies now identify the metazoan RAVE (mRAVE) complex as essential for V-ATPase reassembly and activation under such conditions; map interactions between mRAVE and V-ATPase; and identify a link to CASM, a non-canonical autophagy pathway.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
