Serum copper, zinc and selenium and their ratios as predictors of pneumonia death risk in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-07-10 DOI:10.1007/s15010-025-02596-8

Jaakko T Laine, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen

{"title":"Serum copper, zinc and selenium and their ratios as predictors of pneumonia death risk in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.","authors":"Jaakko T Laine, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen","doi":"10.1007/s15010-025-02596-8","DOIUrl":null,"url":null,"abstract":"Purpose: This study aimed to assess the associations between serum concentrations of copper, zinc and selenium, and pneumonia death risk.Methods: Study included 2088 men from the Kuopio Ischaemic Heart Disease Risk Factor Study aged 42-60 years. Pneumonia deaths were collected by computer linkage to the national Causes of Death Register. Cox proportional hazards regression models, adjusted for multiple variables, were used for analysis.Results: During a mean follow-up of 21.7 years (SD 7.5 years), 139 pneumonia deaths occurred. The multivariable-adjusted hazard ratio for pneumonia death in the highest serum copper-to-zinc-ratio and copper concentration tertiles were 1.75 (95% CI: 1.13-2.71) and 1.64 (95% CI: 1.08-2.50), respectively. Serum zinc concentration showed a statistically significant association with pneumonia death, with the lowest risk observed in the second tertile and no further decrease in risk in the highest tertile. Serum copper-to-selenium ratio nor selenium concentrations were associated with pneumonia death risk.Conclusions: Our findings suggest that a higher serum copper-to-zinc-ratio and higher serum copper concentration are associated with increased risk of pneumonia death, while a higher serum zinc concentration is linked to a decreased risk of pneumonia death in middle-aged and older men.","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s15010-025-02596-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aimed to assess the associations between serum concentrations of copper, zinc and selenium, and pneumonia death risk.

Methods: Study included 2088 men from the Kuopio Ischaemic Heart Disease Risk Factor Study aged 42-60 years. Pneumonia deaths were collected by computer linkage to the national Causes of Death Register. Cox proportional hazards regression models, adjusted for multiple variables, were used for analysis.

Results: During a mean follow-up of 21.7 years (SD 7.5 years), 139 pneumonia deaths occurred. The multivariable-adjusted hazard ratio for pneumonia death in the highest serum copper-to-zinc-ratio and copper concentration tertiles were 1.75 (95% CI: 1.13-2.71) and 1.64 (95% CI: 1.08-2.50), respectively. Serum zinc concentration showed a statistically significant association with pneumonia death, with the lowest risk observed in the second tertile and no further decrease in risk in the highest tertile. Serum copper-to-selenium ratio nor selenium concentrations were associated with pneumonia death risk.

Conclusions: Our findings suggest that a higher serum copper-to-zinc-ratio and higher serum copper concentration are associated with increased risk of pneumonia death, while a higher serum zinc concentration is linked to a decreased risk of pneumonia death in middle-aged and older men.

查看原文本刊更多论文

血清铜、锌和硒及其比值作为男性肺炎死亡风险的预测因子：库奥皮奥缺血性心脏病危险因素研究

目的：本研究旨在评估血清铜、锌和硒浓度与肺炎死亡风险之间的关系。方法：研究对象为来自Kuopio缺血性心脏病危险因素研究的2088名42-60岁男性。肺炎死亡病例通过与国家死亡原因登记册的计算机连接收集。采用多变量校正的Cox比例风险回归模型进行分析。结果：在平均21.7年（SD 7.5年）的随访期间，发生139例肺炎死亡。在血清铜锌比和铜浓度最高的各组中，肺炎死亡的多变量校正风险比分别为1.75 （95% CI: 1.13-2.71）和1.64 （95% CI: 1.08-2.50）。血清锌浓度与肺炎死亡有统计学意义的关联，第二组的风险最低，而最高组的风险没有进一步降低。血清铜硒比与肺炎死亡风险无关。结论：我们的研究结果表明，较高的血清铜锌比和较高的血清铜浓度与肺炎死亡风险增加有关，而较高的血清锌浓度与中老年男性肺炎死亡风险降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.