Electrochemical 1,5-Aryl Migration for Stereo- and Regioselective Synthesis of Tetrasubstituted Alkenes.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-10 DOI:10.1021/acs.orglett.5c02287

Xia-Die Wu,Xian-Bing Luo,Ru-Xi Hu,Meng-Yuan Wu,Zhifang Li,Zhong-Wei Hou,Lei Wang

引用次数: 0

Abstract

An electrochemical 1,5-aryl migration protocol for the stereo- and regioselective synthesis of Se-containing tetrasubstituted α,β-unsaturated amides has been developed. This approach leverages readily available N-benzylpropiolamides and diselenides as starting materials and proceeds without the need for oxidants or metal reagents. The simplicity of the protocol is further enhanced by its execution in a straightforward undivided electrolytic cell at room temperature, providing an efficient and innovative route for the synthesis of challenging tetrasubstituted alkenes.

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电化学1,5-芳基迁移在立体和区域选择性合成四取代烯烃中的应用。

提出了一种用于立体和区域选择性合成含硒四取代α，β-不饱和酰胺的电化学1,5-芳基迁移方案。该方法利用现成的n -苄基丙酰胺和二硒酰胺作为起始材料，无需氧化剂或金属试剂即可进行。该方案的简单性进一步增强了其在室温下直接未分裂的电解槽中的执行，为具有挑战性的四取代烯烃的合成提供了高效和创新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.