Role of non-coding RNA-regulated ferroptosis in colorectal cancer.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-07-08 DOI:10.1038/s41420-025-02606-6

Yan-Peng Zhao, Jun-Liang Liu, Shuai Wang, Xue Li

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Abstract

The recently discovered type of programmed cell death, termed ferroptosis, characterized by an iron-dependent accumulation of lipid peroxides, has been demonstrated to play a pivotal role in the progress of tumors. The role of non-coding RNAs (ncRNAs) in various malignant tumors has also been gradually elucidated in recent years. Colorectal cancer (CRC) is a malignant tumor with a high prevalence and mortality rate worldwide. Many recent studies have demonstrated that the effects of ncRNAs on CRC progression may be mediated by their regulation of ferroptosis. This review first outlines the fundamental mechanisms of ferroptosis and the role of ncRNAs in ferroptosis, and then we summarize the role of ferroptosis in CRC. We then focused on summarizing the effect of ncRNAs regulating ferroptosis in CRC and the recent progress of ferroptosis-related ncRNAs as prognostic biomarkers in CRC patients. This review will help to deepen our understanding of the ncRNA-ferroptosis-CRC axis and inform the study of potential therapeutic targets and prognostic markers for CRC patients.

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非编码rna调控的铁下垂在结直肠癌中的作用。

最近发现的程序性细胞死亡类型，称为铁凋亡，其特征是脂质过氧化物的铁依赖性积累，已被证明在肿瘤的进展中起关键作用。近年来，非编码rna （ncRNAs）在各种恶性肿瘤中的作用也逐渐被阐明。结直肠癌（Colorectal cancer， CRC）是一种在世界范围内发病率和死亡率都很高的恶性肿瘤。最近的许多研究表明，ncrna对CRC进展的影响可能是通过其对铁下垂的调节来介导的。本文首先概述了铁下沉的基本机制和ncrna在铁下沉中的作用，然后对铁下沉在结直肠癌中的作用进行了综述。然后，我们重点总结了ncRNAs在结直肠癌中调控铁凋亡的作用，以及与铁凋亡相关的ncRNAs作为结直肠癌患者预后生物标志物的最新进展。这一综述将有助于加深我们对ncrna -铁凋亡-CRC轴的理解，并为CRC患者潜在治疗靶点和预后标志物的研究提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.