Glucose-Urea-Choline chloride: a versatile catalyst and solvent for the Kabachnik-Fields’ reaction

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-07-03 DOI:10.1016/j.molliq.2025.128079

B. Anupama, Andria Anna Alex, Jisha Mary Thomas, Anila Rose Cherian, Letcy V. Theresa

引用次数: 0

Abstract

Kabachnik-fields reaction is a multi-component organic reaction that gives ⍺-aminophosphonates as products. The reaction between a carbonyl group, an amine, and amino phosphonates is noteworthy due to their antibacterial, antifungal, anti-HIV, anti-cancer, and analgesic characteristics. Low melting mixtures are also good alternatives for toxic catalysts and organic solvents. The use of organic solvent can be reduced in the Kabachnik-fields reaction by using low melting mixtures as a reaction media and catalyst. This method is cost-effective and safe. A practical synthesis of different derivatives of dialkylphosphonates was conducted. The solvent/catalyst is also easily recyclable.

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葡萄糖-尿素-氯化胆碱：卡巴尼克-菲尔兹反应的多功能催化剂和溶剂

卡巴尼克场反应是一种多组分有机反应，产物为氨基膦酸盐。羰基、胺和氨基膦酸盐之间的反应是值得注意的，因为它们具有抗菌、抗真菌、抗艾滋病毒、抗癌和镇痛的特性。低熔点混合物也是有毒催化剂和有机溶剂的良好替代品。通过使用低熔点混合物作为反应介质和催化剂，可以减少卡巴尼克场反应中有机溶剂的使用。该方法经济、安全。对不同的二烷基膦酸盐衍生物进行了实际合成。溶剂/催化剂也很容易回收。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.