Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-07-07 DOI:10.1002/alz.70449

Dimitri B. A. Mantovani, Laura C. Oliveira, Lidia E. W. Spelta, Claudia L. Carvalho, Orestes V. Forlenza, Suely K. N. Marie, Carlos A. Buchpiguel, Artur M. Coutinho, Daniele de Paula Faria

{"title":"Neuroinflammation and amyloid load in different age groups of individuals with Down syndrome: A PET imaging study","authors":"Dimitri B. A. Mantovani, Laura C. Oliveira, Lidia E. W. Spelta, Claudia L. Carvalho, Orestes V. Forlenza, Suely K. N. Marie, Carlos A. Buchpiguel, Artur M. Coutinho, Daniele de Paula Faria","doi":"10.1002/alz.70449","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Down syndrome (DS) is associated with early-onset Alzheimer's disease (AD). This study evaluated neuroinflammation and amyloid beta (Aβ) load in individuals with DS of different ages, using positron emission tomography (PET) imaging.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>DS (<i>n</i> = 29) and age-matched non-DS (<i>n</i> = 35) individuals underwent [<sup>11</sup>C]PK11195 and [<sup>11</sup>C]PiB (Pittsburgh compound B) PET scans, for assessment of neuroinflammation and Aβ load, respectively. Voxel-wise and region-based analyses were conducted, and associations between [<sup>11</sup>C]PK11195 binding and Aβ load were investigated.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Individuals with DS exhibited increased [<sup>11</sup>C]PK11195 binding compared to non-DS controls, with most pronounced differences in older (≥50 years) adults, followed by younger (20–34 years), and intermediate (35–49 years) ages. Among DS participants, 13 individuals were amyloid positive. Associations were observed between [<sup>11</sup>C]PK11195 binding and global Aβ load.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Neuroinflammation in DS follows a region-specific pattern, partially associated with amyloid deposition, and may contribute to the early progression of AD-related pathology.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Neuroinflammation is elevated in Down syndrome (DS) versus age-matched non-DS controls.</li>\n \n <li>Neuroinflammation in DS shows a different pattern depending on the brain region.</li>\n \n <li>[<sup>11</sup>C]PK11195 uptake has a positive monotonic association with amyloid burden.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 7","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70449","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70449","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

Down syndrome (DS) is associated with early-onset Alzheimer's disease (AD). This study evaluated neuroinflammation and amyloid beta (Aβ) load in individuals with DS of different ages, using positron emission tomography (PET) imaging.

METHODS

DS (n = 29) and age-matched non-DS (n = 35) individuals underwent [¹¹C]PK11195 and [¹¹C]PiB (Pittsburgh compound B) PET scans, for assessment of neuroinflammation and Aβ load, respectively. Voxel-wise and region-based analyses were conducted, and associations between [¹¹C]PK11195 binding and Aβ load were investigated.

RESULTS

Individuals with DS exhibited increased [¹¹C]PK11195 binding compared to non-DS controls, with most pronounced differences in older (≥50 years) adults, followed by younger (20–34 years), and intermediate (35–49 years) ages. Among DS participants, 13 individuals were amyloid positive. Associations were observed between [¹¹C]PK11195 binding and global Aβ load.

DISCUSSION

Neuroinflammation in DS follows a region-specific pattern, partially associated with amyloid deposition, and may contribute to the early progression of AD-related pathology.

Highlights

Neuroinflammation is elevated in Down syndrome (DS) versus age-matched non-DS controls.
Neuroinflammation in DS shows a different pattern depending on the brain region.
[¹¹C]PK11195 uptake has a positive monotonic association with amyloid burden.

Abstract Image

查看原文本刊更多论文

不同年龄组唐氏综合征患者的神经炎症和淀粉样蛋白负荷：PET成像研究

唐氏综合征（DS）与早发性阿尔茨海默病（AD）相关。本研究利用正电子发射断层扫描（PET）成像技术评估了不同年龄DS患者的神经炎症和β淀粉样蛋白（Aβ）负荷。方法sds （n = 29）和年龄匹配的非ds （n = 35）分别接受[11C]PK11195和[11C]PiB（匹兹堡化合物B） PET扫描，评估神经炎症和Aβ负荷。进行了基于体素和区域的分析，并研究了[11C]PK11195结合与Aβ负载之间的关系。结果与非DS对照相比，DS患者表现出[11C]PK11195结合增加，在老年人（≥50岁）中差异最明显，其次是年轻人（20-34岁）和中年人（35-49岁）。在DS参与者中，有13人呈淀粉样蛋白阳性。[11C]PK11195结合与整体Aβ负荷之间存在关联。退行性痴呆的神经炎症遵循区域特异性模式，部分与淀粉样蛋白沉积相关，并可能导致ad相关病理的早期进展。与年龄匹配的非唐氏综合征对照组相比，唐氏综合征（DS）患者的神经炎症升高。退行性椎体滑移的神经炎症表现出不同的模式，取决于大脑区域。[11C]PK11195摄取与淀粉样蛋白负荷呈单调正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.