Effects of interval exercise and diurnal variation on blood biomarkers for sport-related concussion: A crossover cohort study.

IF 3 2区医学 Q1 SPORT SCIENCES

Journal of science and medicine in sport Pub Date : 2025-06-24 DOI:10.1016/j.jsams.2025.06.008

Linden C Penner, Jason B Tabor, Joel S Burma, Heather Godfrey, Jean-Michel Galarneau, Jennifer Gradi Cooper, Mohammad Ghodsi, Cheryl L Wellington, Chantel T Debert, Carolyn A Emery, Jonathan D Smirl

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引用次数: 0

Abstract

Objectives: Preliminary investigation of exercise and diurnal effects on neurofilament light, glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1 and total tau.

Methods: Plasma biomarkers were assayed from blood drawn before, during, immediately following, and 1, 2, 4, 6, 8, 24, and 48-h following three exercise conditions completed on a cycle ergometer (control [stationary], moderate intensity interval training and high intensity interval training). Participants with no prior concussion history completed each condition randomized four weeks apart.

Design: Observational, crossover cohort.

Results: Two-hundred-and-ninety-three plasma specimens from 10 participants (7 female, 3 male; median age 23.79 years (interquartile range: 21.38, 25.12)) demonstrated transient decreases in neurofilament light immediately following moderate (-1.11 pg/mL, 95 % confidence interval: -2.08 to -0.13, p = 0.03) and high intensity interval exercise (-1.48 pg/mL, 95 % confidence interval: -2.54 to -0.42, p = 0.01). Glial fibrillary acidic protein also decreased immediately following moderate (-16.47 pg/mL, 95% confidence interval: -28.88 to -4.06, p = 0.01) and high intensity interval exercise (-22.85 pg/mL, 95 % confidence interval: -30.25 to -15.45, p < 0.01), returning to control levels by 1 h post-exercise. Total tau declined throughout the day across all conditions on average (8 h: -1.15 pg/mL, β: 0.63, 95 % confidence interval: 0.44 to 0.89, p < 0.001).

Conclusions: These preliminary findings highlight potential considerations for future sport-related concussion biomarker investigations collecting acute post-injury data in a sports context, as exercise may have immediate transient effects, and diurnal variations may affect plasma concentrations. Future research is needed to examine blood biomarkers affected by exercise and sport-related concussion in populations with consideration for concussion history, age, and sex.

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间歇运动和日变化对运动相关脑震荡血液生物标志物的影响：一项交叉队列研究

目的：初步探讨运动对神经丝光、胶质纤维酸性蛋白、泛素羧基末端水解酶L1和总tau蛋白的影响。方法：在循环测力仪上完成三种运动条件（对照[静止]、中等强度间歇训练和高强度间歇训练）之前、期间、之后以及1、2、4、6、8、24和48小时后采集血液，检测血浆生物标志物。没有脑震荡史的参与者随机间隔四周完成每个条件。设计：观察性交叉队列。结果：10名参与者(女性7人，男性3人；中位年龄23.79岁（四分位数范围：21.38,25.12）)显示，中度（-1.11 pg/mL， 95 %置信区间：-2.08至-0.13,p = 0.03）和高强度间歇运动（-1.48 pg/mL， 95 %置信区间：-2.54至-0.42,p = 0.01）后，神经丝光立即出现短暂性下降。中度运动（-16.47 pg/mL， 95%可信区间：-28.88 ~ -4.06,p = 0.01）和高强度间歇运动（-22.85 pg/mL， 95 %可信区间：-30.25 ~ -15.45,p ）后，胶质原纤维酸性蛋白也立即下降。这些初步研究结果强调了未来在运动背景下收集急性损伤后数据的运动相关脑震荡生物标志物研究的潜在考虑，因为运动可能具有即时的短暂效应，并且日变化可能影响血浆浓度。未来的研究需要在考虑脑震荡病史、年龄和性别的人群中检查受运动和运动相关脑震荡影响的血液生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of science and medicine in sport 医学-运动科学

CiteScore

7.40

自引率

10.00%

发文量

198

审稿时长

48 days

期刊介绍： The Journal of Science and Medicine in Sport is the official journal of Sports Medicine Australia (SMA) and is an an international refereed research publication covering all aspects of sport science and medicine. The Journal considers for publication Original research and Review papers in the sub-disciplines relating generally to the broad sports medicine and sports science fields: sports medicine, sports injury (including injury epidemiology and injury prevention), physiotherapy, podiatry, physical activity and health, sports science, biomechanics, exercise physiology, motor control and learning, sport and exercise psychology, sports nutrition, public health (as relevant to sport and exercise), and rehabilitation and injury management. Manuscripts with an interdisciplinary perspective with specific applications to sport and exercise and its interaction with health will also be considered.