George Gillett, Dan W Joyce, Cedric E Ginestet, James H MacCabe, Nicholas Meyer
{"title":"The network approach to psychopathology: investigating inter-individual variability and the association with clinical relapse in psychosis.","authors":"George Gillett, Dan W Joyce, Cedric E Ginestet, James H MacCabe, Nicholas Meyer","doi":"10.1038/s41537-025-00636-8","DOIUrl":null,"url":null,"abstract":"<p><p>Recent years have seen a proliferation of interest in psychological networks, which conceptualise psychopathology as networks of inter-connected, mutually reinforcing symptoms. It has been hypothesised that the topological structure of such networks is associated with clinical presentation. Analysing data from a longitudinal study of participants diagnosed with psychosis, we identify substantial inter-individual variability in network structure, problematising causal inference from cross-sectional networks. Additionally, we do not find strong evidence for an association between network structure and clinical relapse.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"11 1","pages":"94"},"PeriodicalIF":4.1000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229628/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia (Heidelberg, Germany)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41537-025-00636-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Recent years have seen a proliferation of interest in psychological networks, which conceptualise psychopathology as networks of inter-connected, mutually reinforcing symptoms. It has been hypothesised that the topological structure of such networks is associated with clinical presentation. Analysing data from a longitudinal study of participants diagnosed with psychosis, we identify substantial inter-individual variability in network structure, problematising causal inference from cross-sectional networks. Additionally, we do not find strong evidence for an association between network structure and clinical relapse.