Plasma Lipidomic Profiles Investigating the Effects of Combined Therapy With Quetiapine and Magnesium Valproate in Emerging Adults With Bipolar II Disorder During Depressive Episodes: A Follow-Up Study

IF 4 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yanhua Chen, Yan Yao, Chujun Wu, Hui Li, Manxue Zhang, Zhengwu Peng
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Abstract

Bipolar disorder (BD) is associated with alterations in plasma lipid profiles, which may contribute to its pathogenesis. However, the detailed plasma lipidomic composition of bipolar II disorder during depressive episodes (BPD-II) remains underexplored. This study investigates the temporal changes in plasma lipidomics in BPD-II patients at emerging adulthood undergoing treatment with quetiapine combined with magnesium valproate. We conducted a follow-up study involving individuals with BPD-II at emerging adulthood at baseline (BD-BL, n = 30), 3 weeks (BD-3w, n = 30), and 8 weeks (BD-8w, n = 30) after treatment initiation, as well as gender- and age-matched healthy controls (HC, n = 30). Plasma lipidomics were analyzed using a comprehensive lipidomic profiling approach to identify potential biomarkers. Significant differences in plasma lipid composition were observed between BPD-II patients and healthy controls. Treatment with quetiapine combined with magnesium valproate alleviated symptoms in a time-dependent manner, although residual symptoms persisted after 8 weeks. We identified 64 lipid species with diagnostic potential to distinguish BPD-II from HC and 42 lipid species that could predict treatment outcomes with high reliability. Our findings provide valuable insights into the therapeutic effects of quetiapine combined with magnesium valproate and highlight the potential role of plasma lipidomics in understanding the pathophysiology of BPD-II at emerging adulthood.

Abstract Image

血浆脂质组学研究喹硫平和丙戊酸镁联合治疗新发成人双相II型障碍抑郁发作期的效果:一项随访研究
双相情感障碍(BD)与血浆脂质谱的改变有关,这可能是其发病机制的一部分。然而,抑郁发作期间双相情感障碍II (BPD-II)的详细血浆脂质组学组成仍未得到充分研究。本研究探讨了接受喹硫平联合丙戊酸镁治疗的成年早期BPD-II患者血浆脂质组学的时间变化。我们进行了一项随访研究,纳入了治疗开始后初成年期BPD-II患者的基线(BD-BL, n = 30)、3周(BD-3w, n = 30)和8周(BD-8w, n = 30),以及性别和年龄匹配的健康对照(HC, n = 30)。采用全面的脂质组学分析方法对血浆脂质组学进行分析,以确定潜在的生物标志物。BPD-II患者与健康对照者血浆脂质组成有显著差异。喹硫平联合丙戊酸镁治疗以时间依赖性方式缓解症状,尽管残留症状在8周后持续存在。我们确定了64种具有区分BPD-II和HC诊断潜力的脂质,42种脂质可以高可靠性地预测治疗结果。我们的研究结果为喹硫平联合丙戊酸镁的治疗效果提供了有价值的见解,并强调了血浆脂质组学在了解成年早期BPD-II病理生理方面的潜在作用。
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来源期刊
Journal of Neurochemistry
Journal of Neurochemistry 医学-神经科学
CiteScore
9.30
自引率
2.10%
发文量
181
审稿时长
2.2 months
期刊介绍: Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.
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