“Therapies Through Gut:” Targeted Drug Delivery for Non-Gastrointestinal Diseases by Oral Administration (Adv. Healthcare Mater. 17/2025)

Abstract

Targeted Therapies Through Gut

Oral drug delivery holds promise for treating non-gastrointestinal diseases but faces barriers like intestinal permeability and low bioavailability. Targeted nanoparticles using ligands like chitosan, butyrate, and yeast capsules improve absorption and release. Despite progress in crossing the intestinal barrier to treat conditions like cancer and fibrosis, challenges in stability and efficacy remain key considerations. More details can be found in article 2403162 by Hang Thu Ta and co-workers.