A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals (Adv. Healthcare Mater. 17/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-07-04 DOI:10.1002/adhm.202570101

Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang

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引用次数: 0

Abstract

Parkinson's Disease

Wireless graphene-based cortical surface implant restores motor function in Parkinsonian rats by recording pathogenic beta–gamma oscillations and delivering on-demand high-frequency stimulation that rebalances delta rhythms, strengthens mGluR5- and D5R-mediated synaptic plasticity, and upregulates glutamatergic genes. The flexible, biocompatible, minimally invasive system demonstrates integrated real-time diagnosis and therapy for neurodegenerative disorders across multiple freely moving animals. More details can be found in article 2405179 by Sungchil Yang, Sung Q Lee, Sunggu Yang, and co-workers.

Abstract Image

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一种用于诊断和缓解自由运动动物帕金森病症状的无线皮质表面植入物（Adv. Healthcare Mater. 17/2025）

帕金森氏病基于石墨烯的皮质表面无线植入通过记录致病性β - γ振荡和提供按需高频刺激来恢复帕金森大鼠的运动功能，这种刺激可以重新平衡delta节律，增强mGluR5-和d5r介导的突触可塑性，并上调谷氨酸能基因。这种灵活的、生物相容性的、微创的系统展示了对多种自由活动动物神经退行性疾病的综合实时诊断和治疗。更多细节可以在Sungchil Yang， Sung Q Lee， Sunggu Yang及其同事的文章2405179中找到。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.