The prevalence of apathy in Lewy body dementia: A systematic review and meta-analysis

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-07-03 DOI:10.1002/alz.70425

Jenny Jia Yu, Kai Sin Chin, Paula M. Loveland, Leonid Churilov, Samantha M. Loi, Nawaf Yassi, Rosie Watson

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引用次数: 0

Abstract

INTRODUCTION

Apathy is an important syndrome in Lewy body dementia (LBD), although reported prevalences vary. We aimed to estimate the prevalence of apathy in LBD through systematic review and meta-analysis.

METHODS

Five databases were searched for articles reporting the prevalence of apathy in LBD (dementia with Lewy bodies [DLB] and Parkinson's disease dementia [PDD]) and prodromal/mild cognitive impairment (MCI) LBD. Linear mixed model random effect meta-analysis was performed to determine the prevalence of apathy.

RESULTS

Of 7846 articles identified, 49 met inclusion criteria. The average pooled prevalence of apathy was 57% (95% confidence interval [CI] 52%–63%, I² = 85.6%) in DLB, 56% (95% CI 43%–70%, I² = 97.6%) in PDD, 46% (95% CI 32%–61%, I² = 90.6%) in Lewy body-MCI, and 38% (95% CI 25%–50%, I² = 88.1%) in Parkinson's disease-MCI.

DISCUSSION

Apathy affects more than half of individuals with LBD. The high prevalence in prodromal DLB supports the notion that apathy may assist in more timely and accurate diagnosis of DLB.

Highlights

Reported apathy prevalence in Lewy body dementia (LBD) varies widely in the existing literature.
The pooled prevalence of apathy was > 50% in LBD and > 40% in prodromal disease stages.
Apathy may have utility in earlier, more accurate diagnosis of dementia with Lewy bodies.

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路易体痴呆患者冷漠的患病率：系统回顾和荟萃分析

冷漠是路易体痴呆（LBD）的一个重要症状，尽管报道的患病率各不相同。我们的目的是通过系统回顾和荟萃分析来估计LBD中冷漠的患病率。方法检索5个数据库，检索报道LBD（路易体痴呆[DLB]和帕金森病痴呆[PDD]）和前驱/轻度认知障碍（MCI） LBD中冷漠患病率的文章。采用线性混合模型随机效应荟萃分析来确定冷漠的患病率。结果在7846篇文献中，49篇符合纳入标准。DLB患者冷漠的平均总患病率为57%(95%可信区间[CI] 52%-63%， I2 = 85.6%)， PDD患者为56% (95% CI 43%-70%, I2 = 97.6%)，路易体- mci患者为46% (95% CI 32%-61%, I2 = 90.6%)，帕金森病- mci患者为38% （95% CI 25%-50%, I2 = 88.1%）。冷漠影响了超过一半的LBD患者。前驱DLB的高患病率支持冷漠可能有助于更及时和准确诊断DLB的概念。在路易体痴呆（LBD）中报道的冷漠患病率在现有文献中差异很大。冷漠的总患病率为>；50%在LBD和>；40%在前驱疾病阶段。冷漠可能有助于早期更准确地诊断路易体痴呆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.