Photoinduced Three-Component 1,2-Dicarbofunctionalization of Unactivated Alkenes via Polarity-Matched Control.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-03 DOI:10.1021/acs.orglett.5c02518

Panyi Huang,Ting He,Xinyu Li,Bin Sun,Yongmin Ma

引用次数: 0

Abstract

We herein present a polarity-matched, light-induced radical strategy that enables the direct 1,2-heteroarylalkylation of alkenes using a range of commercially available alkyl bromides and heteroarenes under catalyst- and additive-free conditions. This transformation proceeds under mild reaction conditions, exhibits excellent chemoselectivity, and demonstrates a broad substrate scope (42 examples), including derivatives of pharmaceuticals and natural products.

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极性匹配控制下非活化烯烃的光诱导三组分1,2-二碳功能化。

在此，我们提出了一种极性匹配的光诱导自由基策略，可以在无催化剂和无添加剂的条件下，使用一系列市售的溴化烷基和杂芳烃直接进行1,2-杂芳烃烷基化。这种转化在温和的反应条件下进行，表现出优异的化学选择性，并展示了广泛的底物范围（42个例子），包括药物和天然产物的衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.