The Efficacy and Safety of Single Injections of Hybrid HA in the Treatment of Symptomatic Knee Osteoarthritis: A Case Series.

IF 2.9 3区医学 Q2 RHEUMATOLOGY

Rheumatology and Therapy Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI:10.1007/s40744-025-00780-8

Marcin E Domzalski, Klaudia Marchewa

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引用次数: 0

Abstract

Introduction: The prevalence of knee osteoarthritis (OA) is rising worldwide, leading to disability and a reduced quality of life, particularly in elderly patients. While there are several treatment options, there is little consensus in the scientific community over which methods are most effective. Viscosupplementation with hyaluronic acid (HA) has been found to reduce pain in patients with knee OA over a period of up to 6 months, with little to no side effects. The aim of this prospective open-label, uncontrolled, observational, single-site study was to assess the efficacy and safety of a single hybrid HA injection over a period of 6 months in subpopulations of patients with low to severe symptomatic knee OA in everyday clinical practice.

Methods: Fifty patients who met the inclusion criteria participated in the study. A single intra-articular ultrasound-guided injection of hybrid HA (Sinovial®) was administered. Patients submitted Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaires at 28, 42, 84, and 168 days post-treatment.

Results: VAS scores measured at rest and when walking indicate an improvement during follow-up, particularly at 28 and 42 days, compared to baseline. Similarly, the most notable improvement of the WOMAC score was observed within the first 42 days after injection. While decrease in pain and joint function improvement were not as pronounced at the end of follow-up, they were still statistically better than at baseline. Overall patient satisfaction was high.

Conclusion: Treatment with a single injection of hybrid HA was demonstrated to be safe and effective in patients with varying degrees of knee OA. Patients with medial knee OA responded better to treatment than patients with patellofemoral OA, which provides information on which types of patients are best suited to this intervention.

Trial registration: ClinicalTrials.gov identifier, NCT06652893. Retrospectively registered October 10, 2024.

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单次注射混合透明质酸治疗症状性膝骨关节炎的疗效和安全性：一个病例系列。

膝骨关节炎（OA）的患病率在全球范围内不断上升，导致残疾和生活质量下降，特别是在老年患者中。虽然有几种治疗方案，但科学界对哪种方法最有效几乎没有共识。透明质酸（HA）粘胶补充剂已被发现可以减轻膝关节OA患者长达6个月的疼痛，几乎没有副作用。这项前瞻性、开放标签、非对照、观察性、单点研究的目的是评估在日常临床实践中，单次混合HA注射对低重度症状性膝关节炎患者亚群的疗效和安全性，为期6个月。方法：50例符合纳入标准的患者参与研究。超声引导下单次关节内注射混合HA （Sinovial®）。患者在治疗后28、42、84和168天提交视觉模拟量表（VAS）和西安大略省和麦克马斯特大学关节炎指数（WOMAC）问卷。结果：与基线相比，休息和行走时的VAS评分表明随访期间有所改善，特别是在28天和42天。同样，WOMAC评分在注射后42天内的改善最为显著。虽然在随访结束时疼痛的减轻和关节功能的改善没有那么明显，但在统计学上仍比基线时好。患者总体满意度较高。结论：单次注射混合透明质酸治疗不同程度膝关节炎是安全有效的。内侧膝OA患者比髌骨OA患者对治疗的反应更好，这为哪种类型的患者最适合这种干预提供了信息。试验注册：ClinicalTrials.gov识别码，NCT06652893。追溯登记于2024年10月10日。

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来源期刊

Rheumatology and Therapy RHEUMATOLOGY-

CiteScore

6.00

自引率

5.30%

发文量

审稿时长

6 weeks

期刊介绍： Aims and Scope Rheumatology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of rheumatologic therapies. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. Areas of focus include, but are not limited to, rheumatoid arthritis, gout, gouty arthritis, psoriatic arthritis, osteoarthritis, juvenile idiopathic/rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis, Pompe’s disease, inflammatory joint conditions, musculoskeletal conditions, systemic sclerosis, and fibromyalgia. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial protocols, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Rheumatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research. Ethics and Disclosures The journal is a member of the Committee on Publication Ethics (COPE) and subscribes to its principles on how to deal with acts of misconduct thereby committing to investigate allegations of misconduct in order to ensure the integrity of research. Content in this journal is peer-reviewed (Single-blind). 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