Clival osteomyelitis as a rare complication of paediatric melioidosis.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Nicole Phing Jie Hoo, Sin Toun Loh, Ann Li Lo, David Chun-Ern Ng
{"title":"Clival osteomyelitis as a rare complication of paediatric melioidosis.","authors":"Nicole Phing Jie Hoo, Sin Toun Loh, Ann Li Lo, David Chun-Ern Ng","doi":"10.1136/bcr-2025-266603","DOIUrl":null,"url":null,"abstract":"<p><p>We report a rare case of melioidosis presenting with submandibular and parotid abscesses, complicated by clival osteomyelitis in a child. Diagnosis was confirmed by molecular testing of pus samples and a positive serology for <i>Burkholderia pseudomallei</i> despite negative blood cultures. The patient initially received intravenous ceftazidime and oral trimethoprim-sulfamethoxazole (TMP-SMX). However, she developed hypersensitivity reactions to TMP-SMX, requiring a switch to oral amoxicillin-clavulanate. She responded well with complete resolution of the submandibular and parotid abscesses after 4 weeks of treatment. This case emphasises the importance of a high index of suspicion of melioidosis in endemic regions due to its diverse clinical presentation and diagnostic challenges.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"18 7","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/bcr-2025-266603","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

We report a rare case of melioidosis presenting with submandibular and parotid abscesses, complicated by clival osteomyelitis in a child. Diagnosis was confirmed by molecular testing of pus samples and a positive serology for Burkholderia pseudomallei despite negative blood cultures. The patient initially received intravenous ceftazidime and oral trimethoprim-sulfamethoxazole (TMP-SMX). However, she developed hypersensitivity reactions to TMP-SMX, requiring a switch to oral amoxicillin-clavulanate. She responded well with complete resolution of the submandibular and parotid abscesses after 4 weeks of treatment. This case emphasises the importance of a high index of suspicion of melioidosis in endemic regions due to its diverse clinical presentation and diagnostic challenges.

斜坡骨髓炎是小儿类鼻疽症的罕见并发症。
我们报告一个罕见的病例类鼻疽表现为下颌骨和腮腺脓肿,并发斜坡骨髓炎的儿童。虽然血培养阴性,但脓液样本的分子检测和假性伯克霍尔德菌血清学阳性证实了诊断。患者最初接受头孢他啶静脉注射和口服甲氧苄啶-磺胺甲恶唑(TMP-SMX)。然而,她出现了对TMP-SMX的过敏反应,需要改用口服阿莫西林-克拉维酸。经过4周的治疗,她的下颌下和腮腺脓肿完全消退。该病例强调了在流行地区高度怀疑类鼻疽的重要性,因为其临床表现和诊断挑战各不相同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMJ Case Reports
BMJ Case Reports Medicine-Medicine (all)
CiteScore
1.40
自引率
0.00%
发文量
1588
期刊介绍: BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信