Sandra Giménez, Lídia Vaqué-Alcázar, Nuole Zhu, Bessy Benejam, Javier Arranz, Lucia Maure-Blesa, Laura Videla, Maria Carmona-Iragui, Isabel Barroeta, Anne-Sophie Rebillat, Íñigo Rodríguez-Baz, Alexandre Bejanin, José Enrique Arriola-Infante, Ana Bueno, Susana Fernandez, Laia Ribas, Sara E. Zsadanyi, Alejandra O. Morcillo-Nieto, Daniel Alcolea, Christos Panagiotis Lisgaras, Esther Blessing, Ricardo S. Osorio, Alberto Lleó, Juan Fortea
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Abstract
INTRODUCTION
Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum.
METHODS
We studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography.
RESULTS
Adults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders.
CONCLUSIONS
In DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression.
Highlights
Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep.
Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS.
Age-related decreases in SWS and REM sleep are accelerated in DS.
Subjective sleep measures do not detect sleep disturbances in adults with DS.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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