Chronic hepatitis B virus persistence: Mechanisms, consequences and implications for achieving cure.

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-06-26 DOI:10.1016/j.aohep.2025.101938

Christopher Georgi, Simmone D'souza, Carla Osiowy, Carla S Coffin, Curtis L Cooper

引用次数: 0

Abstract

HBV persists within the hepatocyte due to the presence of intranuclear covalently closed circular DNA (cccDNA) and double-stranded linear DNA (dslDNA) integration. These bodies pose formidable challenges for achieving HBV functional and sterilizing cure. In this virology-focused review we provide an overview of HBV persistence with consideration of the negative implications for chronic infection. We also discuss advancements in HBV therapies that aim to disrupt these targets.

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慢性乙型肝炎病毒持久性：实现治愈的机制、后果和意义。

由于存在核内共价闭合环状DNA （cccDNA）和双链线性DNA （dslDNA）整合，HBV在肝细胞内持续存在。这些机体对实现乙型肝炎病毒的功能性和绝育性治疗提出了巨大的挑战。在这篇以病毒学为重点的综述中，我们提供了HBV持久性的概述，并考虑了慢性感染的负面影响。我们还讨论了旨在破坏这些靶点的HBV治疗的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.