Inactivated Mycobacterial Vaccine Nebulized Inhalation: A Effective Therapy for the Prevention and Treatment of Respiratory Diseases?

IF 2.3 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2025-07-01 DOI:10.1111/crj.70101

Xiaohong Jiang, Qixiang Sun, Yujia Huang, Yuetian Deng, Chaoqian Li

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引用次数: 0

Abstract

Nebulized inhalation therapy is an important method in the prevention and treatment of respiratory diseases, and inactivated mycobacterial vaccine nebulized inhalation has received a wide attention recently, but the roles and mechanisms are still not fully understood. A literature search showed there is a strong scientific rationale and evidence that nebulized inhalation of inactivated mycobacterial vaccine is effective in the prevention and treatment of respiratory diseases. Clinically available mycobacterial vaccines include Mycobacterium phlei (M. phlei), BCG, and Mycobacterium vaccae (M. vaccae). Nebulized inhalation of inactivated mycobacterial vaccine, especially M. vaccae, has been used in the prevention and treatment of respiratory diseases, such as asthma, respiratory syncytial virus (RSV), coronavirus disease 2019 (COVID-19), and sepsis. It acts on the respiratory tract directly, thus stimulating the body to produce an immune response, enhance respiratory immunity, and achieve prevention and treatment effects. Nebulized inhalation of inactivated mycobacterial vaccine will be an effective therapy in the prevention and treatment of respiratory diseases.

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雾化吸入灭活分枝杆菌疫苗：预防和治疗呼吸系统疾病的有效方法？

雾化吸入治疗是预防和治疗呼吸系统疾病的一种重要方法，而灭活分枝杆菌疫苗雾化吸入近年来受到了广泛的关注，但其作用和机制尚不完全清楚。文献检索显示，有强有力的科学依据和证据表明，雾化吸入灭活分枝杆菌疫苗可有效预防和治疗呼吸道疾病。临床可用的分枝杆菌疫苗包括phlei分枝杆菌（M. phlei）、BCG和母牛分枝杆菌（M.母牛）。雾化吸入灭活分枝杆菌疫苗，特别是母牛分枝杆菌疫苗，已被用于预防和治疗呼吸道疾病，如哮喘、呼吸道合胞病毒（RSV）、冠状病毒病2019 （COVID-19）和败血症。它直接作用于呼吸道，从而刺激机体产生免疫反应，增强呼吸道免疫力，达到防治效果。雾化吸入灭活分枝杆菌疫苗将是预防和治疗呼吸系统疾病的有效方法。

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)