Three-component copper-catalyzed difluoroalkylamidation of alkynes: An efficient approach to difluoroalkylated enamides

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-07-01 DOI:10.1039/d5qo00751h

Jing Ren, Kaiyun Liu, Jinlong Li, Xinyu Long, Kaizhi Li

引用次数: 0

Abstract

This paper describes a selective three-component 1,2-difluoroalkylamidation of alkynes enabled by a coordinating activation strategy. This protocol utilizes commercially available difluoroalkyl halides as radical precursors and picolinamides as nitrogen sources, facilitating the synthesis of difluoroalkylated enamides with broad substrate scope, good functional group compatibility, and exceptional stereoselectivity. The modular catalytic synthesis is characterized by its ease of implementation, broad molecular diversity, and flexibility in late-stage modifications.

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三组分铜催化炔的二氟烷基酰胺化：制备二氟烷基酰胺的有效方法

本文描述了一种选择性的三组分1,2-二氟烷基酰胺化的协调活化策略。该方案利用市售的二氟烷基卤化物作为自由基前体，吡啶酰胺作为氮源，促进合成具有广泛底物范围、良好官能团相容性和特殊立体选择性的二氟烷基酰胺。模块化催化合成的特点是其易于实施，广泛的分子多样性和后期修饰的灵活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.