The role of miR-4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

Abstract

As a pivotal microRNA (miRNA), miR-4284 exhibits noteworthy aberrant expression levels across various cancers and diseases, exerting a crucial role in modulating cancer progression and prognosis. This article endeavors to comprehensively elucidate the regulatory mechanisms of miR-4284 in cancer, delving deeply into its impact on tumor cell proliferation, invasion, and metastasis by intervening in key signaling pathways such as p65, mitogen-activated protein kinase (MAPK), and transforming growth factor-β (TGF-β). Moreover, this article examines the potential associations of miR-4284 with diverse current therapeutic strategies, such as cancer prediction models, synergistic effects of chemotherapeutic agents, mechanisms of ultrasound-targeted microbubble destruction technology, and enhancement of radiotherapy. However, despite the significant strides made in miR-4284 research, certain limitations persist. Looking ahead, we anticipate that larger-scale and more in-depth studies will further unveil the functional mechanisms of miR-4284 and elucidate its role in therapeutic drug efficacy, thus furnishing robust theoretical underpinnings for the clinical application of miR-4284.