Front Cover: A Mild and Catalyst-Free Synthesis of Cannabidiols and Regioisomers Mediated by Fluorinated Alcohols (Chem. Asian J. 12/2025)

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2025-06-27 DOI:10.1002/asia.202581201

Phanomsak Yukhet, Kriangsak Faikhruea, Rewadee Mowang, Phiphob Naweephattana, Manussada Ratanasak, Yasuteru Shigeta, Thanyada Rungrotmongkol, Chanat Aonbangkhen, Tirayut Vilaivan

引用次数: 0

Abstract

In article number e202401648 by Tirayut Vilaivan and co-workers, an environmentally benign synthesis of cannabidiols (CBDs) in fluorinated alcohol solvents is presented. The hexafluoroisopropanol-mediated Friedel-Crafts reaction between p-menthadienol and 5-alkyl resorcinols proceeds under mild conditions to afford CBDs and regioisomers without additional catalysts. DFT calculations provide insights into the active roles of fluorinated alcohols and the selectivity of product formation.

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封面：温和和无催化剂合成大麻二酚和区域异构体介导的氟化醇(化学。亚洲J. 12/2025)

在Tirayut Vilaivan及其同事的文章e202401648中，介绍了在氟化醇溶剂中无害地合成大麻二酚（CBDs）的方法。六氟异丙醇介导的对薄荷二醇和5-烷基间苯二酚之间的Friedel-Crafts反应在温和的条件下进行，无需额外的催化剂即可产生cbd和区域异构体。DFT计算为氟化醇的活性作用和产物形成的选择性提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).