Lipids rewire T cell exhaustion

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-06-27 DOI:10.1038/s41590-025-02177-9

Marie-Elen Tuchel, Annette Oxenius

引用次数: 0

Abstract

CD8+ T cell exhaustion and dysfunction are features of a number of diseases associated with chronic antigen exposure and in some cases can be overcome with checkpoint-blocking therapies. Researchers are now investigating the crosstalk between cellular exhaustion and metabolism with a focus on the role of lipid mediators and redox biology.

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脂质重新连接T细胞衰竭

CD8+ T细胞耗竭和功能障碍是许多与慢性抗原暴露相关的疾病的特征，在某些情况下可以通过检查点阻断疗法来克服。研究人员目前正在研究细胞衰竭和代谢之间的串扰，重点关注脂质介质和氧化还原生物学的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.