Considerations in the selection of patient-reported outcome measures for assessing function related to chronic ankle instability.

IF 4.8 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-06-10 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1602283

Lijiang Luan, Jeremy Witchalls, Phil Newman, Adrian Pranata, Charlotte Ganderton, Oren Tirosh, Doa El-Ansary, Roger David Adams, Gordon Waddington, Jia Han

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Abstract

Patient-reported outcome measures (PROMs) are essential tools in evaluating chronic ankle instability (CAI), capturing subjective experiences such as "giving way" and instability. However, no standardized guidelines exist for selecting PROMs in CAI, resulting in limited comparability across studies and clinical settings. This paper highlights four key considerations for selecting PROMs in assessing CAI: recalibration in populations including individuals with CAI, identifiability of ankle instability, detectability of CAI characteristics, and cross-cultural adaptability. It emphasizes that CAI-specific PROMs should demonstrate high pertinence, accurately distinguishing CAI from other conditions, and effectively detecting symptom changes over time. Furthermore, widely adopted PROMs may offer greater credibility and applicability. Addressing these considerations is crucial for improving CAI diagnosis, treatment evaluation, and advancing patient-centered care.

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选择患者报告的评估慢性踝关节不稳定相关功能的结果指标时的考虑。

患者报告的结果测量（PROMs）是评估慢性踝关节不稳定（CAI）的重要工具，捕捉主观体验，如“让位”和不稳定。然而，在CAI中选择prom没有标准化的指南，导致研究和临床设置之间的可比性有限。本文强调了在评估CAI时选择PROMs的四个关键考虑因素：包括CAI患者在内的人群的重新校准，踝关节不稳定的可识别性，CAI特征的可检测性以及跨文化适应性。它强调CAI特异性prom应具有高针对性，能够准确地将CAI与其他疾病区分开来，并有效地检测症状随时间的变化。此外，广泛采用的prom可以提供更大的可信度和适用性。解决这些问题对于改进CAI诊断、治疗评估和推进以患者为中心的护理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.