Norcolocynins A and B, Ring B seco-Norcucurbitane Triterpenoids from the Fruits of Citrullus colocynthis and Their Cytotoxicity.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-25 DOI:10.1021/acs.orglett.5c02010

Zhi-Qiang Zhao,Xue-Rui An,Xue Tian,Heng-Wei Zhou,Tian-Zhi Li,Wei Liu,Tao Yuan

引用次数: 0

Abstract

Two unprecedented ring-B seco-norcucurbitane triterpenoids, norcolocynins A (1) and B (2), were isolated from Citrullus colocynthis fruits. The determination of their structures was based on the extensive analysis of spectroscopic data as well as X-ray crystallography. A biogenetic route for 1 involving a decarboxylation, followed by a rearrangement of 2 is proposed. Cytotoxicity assay revealed that 2 showed moderate activity against HCT116 cells (IC50 = 27.92 ± 0.80 μM), comparable to that of positive control cisplatin.

查看原文本刊更多论文

去甲绿霉素A、B、环二-去甲绿烷三萜及其细胞毒性研究。

从瓜泥果实中分离到两个前所未有的环-B二去甲葫芦烷三萜：去甲石榴素A(1)和B(2)。其结构的确定是基于对光谱数据和x射线晶体学的广泛分析。提出了1的生物遗传途径，包括脱羧，然后是2的重排。细胞毒实验显示，2对HCT116细胞有中等抑制作用（IC50 = 27.92±0.80 μM），与阳性对照顺铂相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.