Case Report: A comprehensive case study on aggressive high-grade urothelial carcinoma of bladder that transforms into enteric-type adenocarcinoma along with an integrated treatment approach.

Frontiers in radiology Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI:10.3389/fradi.2025.1586440
Neha Rahul, Manishimwe Jules, Induni Nayodhara Weerarathna, Anurag Luharia, Prashik Dube
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Abstract

Bladder cancer is a malignant tumour with a high morbidity and mortality rate in the world. Moreover, it is the most prevalent as well as commonly diagnosed in older individuals, with a median age of 73 years, and it has been reported that the most frequently seen histological type of bladder cancer was urothelial carcinoma. We present a unique case of a 44-year-old female with enteric-type adenocarcinoma, a rare and aggressive bladder cancer. Her symptoms included frequent micturition (Urination) and hematuria (blood in urine), at which point she was diagnosed with High-grade urothelial carcinoma. The malignancy worsened despite cycles of treatment requiring extensive surgery. After further tests, it was found that she had urothelial carcinoma with features of intestinal tissue (tissue of the intestine) and that the disease had infiltrated into nearby blood vessels and nerves. Radiation therapy was recommended to decrease the risk of local recurrence after surgery. The challenges in treating such a patient and the positive aspects this approach can give are highlighted in a case report.

病例报告:一个侵袭性高级别膀胱尿路上皮癌转化为肠型腺癌的综合病例研究以及综合治疗方法。
膀胱癌是世界上发病率和死亡率较高的恶性肿瘤。此外,它在老年人中最普遍,也最常被诊断出来,中位年龄为73岁,据报道,最常见的膀胱癌的组织学类型是尿路上皮癌。我们报告一例44岁女性肠型腺癌,一种罕见的侵袭性膀胱癌。她的症状包括尿频和血尿,此时她被诊断为高级别尿路上皮癌。恶性肿瘤恶化,尽管周期治疗需要广泛的手术。进一步检查后,发现她患有以肠组织(肠组织)为特征的尿路上皮癌,并已浸润到附近的血管和神经。建议放射治疗以降低手术后局部复发的风险。在治疗这样的病人的挑战和积极的方面,这种方法可以给一个病例报告强调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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