{"title":"Microinvasive Carcinoma of the Breast.","authors":"Rachel Han, Edi Brogi","doi":"10.1016/j.humpath.2025.105856","DOIUrl":null,"url":null,"abstract":"<p><p>Microinvasive breast carcinoma is a diagnostically subtle form of invasive breast carcinoma with poorly characterized biologic behavior and limited evidence to guide treatment. This review addresses: (i) diagnostic criteria for microinvasive breast carcinoma; (ii) epidemiology and clinical features; (iii) histopathologic findings, including practical diagnostic clues and use of immunohistochemistry; (iv) biomarker assessment; and (v) current clinical management strategies and challenges.</p>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":" ","pages":"105856"},"PeriodicalIF":2.7000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.humpath.2025.105856","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Microinvasive breast carcinoma is a diagnostically subtle form of invasive breast carcinoma with poorly characterized biologic behavior and limited evidence to guide treatment. This review addresses: (i) diagnostic criteria for microinvasive breast carcinoma; (ii) epidemiology and clinical features; (iii) histopathologic findings, including practical diagnostic clues and use of immunohistochemistry; (iv) biomarker assessment; and (v) current clinical management strategies and challenges.
期刊介绍:
Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.