Once-weekly insulin efsitora alfa versus once-daily insulin glargine U100 in adults with type 2 diabetes treated with basal and prandial insulin (QWINT-4): a phase 3, randomised, non-inferiority trial

Thomas Blevins MD, Dominik Dahl MD, Federico C Pérez Manghi MD, Sreenivasa Murthy MD, Ramon Ortiz Carrasquillo MD, Xiaoqi Li PhD, Annette M Chang MD, Molly C Carr MD, Michelle Katz MD
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Abstract

Insulin efsitora alfa (efsitora), a once-weekly basal insulin, has the potential to reduce the treatment burden of people with type 2 diabetes who require insulin. We aimed to assess the efficacy and safety of once-weekly efsitora compared with insulin glargine U100 in adults with type 2 diabetes treated with basal and prandial insulin.
在接受基础和膳食胰岛素治疗的成人2型糖尿病患者(QWINT-4)中,每周一次的α -胰岛素与每日一次的甘精胰岛素U100:一项3期、随机、非劣效性试验
每周一次的基础胰岛素(efsitora)有可能减轻需要胰岛素的2型糖尿病患者的治疗负担。我们的目的是评估每周一次的efsitora与甘精胰岛素U100在接受基础胰岛素和膳食胰岛素治疗的成人2型糖尿病患者中的疗效和安全性。
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