Molecular evolution of sour tolerance in birds.

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-06-19 DOI:10.1126/science.adr7946

Hao Zhang, Lei Luo, Qiaoyi Liang, Lifeng Tian, Yong Shao, Xiuping Zhang, Kaixun Cao, Anna Luo, Chengsan Wang, Peter Muiruri Kamau, Dong-Dong Wu, Maude W Baldwin, Ren Lai

引用次数: 0

Abstract

Taste is crucial in shaping animal perception. Sourness, one of the primary tastes, is aversive in mammals, whereas many birds frequently consume acidic fruits, suggesting a potential tolerance. Our study uncovers a mechanism enabling avian sour tolerance that involves changes to the sour receptor [otopetrin 1 (OTOP1)]. We demonstrate that sour tolerance is a conserved trait in birds, with avian OTOP1 exhibiting acid-induced inhibition and OTOP1 modulation affecting sour perception and tolerance. Ancestral reconstruction reveals that the increase in acid tolerance may have evolved at the same point in the songbird phylogeny as the regain of sweet sensing in this clade. This shift might have enabled songbirds to feed on a wider range of fruits, affecting the evolution and diversification of the songbird radiation.

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鸟类耐酸性的分子进化。

味觉在塑造动物感知能力方面起着至关重要的作用。哺乳动物最主要的味道之一是酸，而许多鸟类经常食用酸性水果，这表明它们有潜在的耐受性。我们的研究揭示了一种使鸟类耐受酸的机制，这种机制涉及到酸受体[otopetrin 1 (OTOP1)]的变化。研究表明，鸟类对酸的耐受性是一种保守的性状，鸟类的OTOP1表现出酸诱导的抑制作用，而OTOP1的调节作用影响了对酸的感知和耐受性。祖先重建表明，酸耐受性的增加可能是在鸣禽系统发育的同一时间点进化而来的，这一进化支中重新获得了对甜味的感知。这种转变可能使鸣禽能够以更广泛的水果为食，影响了鸣禽辐射的进化和多样化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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