Co-occurence of amyotrophic lateral sclerosis and sarcoidosis: a case report and systematic review of the literature.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-06-20 DOI:10.1007/s10072-025-08299-0

Luigi Bonan, Marcello Bombardi, Andrea Di Lionardo, Maria Vitiello, Simonetta Morresi, Marco Longoni

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引用次数: 0

Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons, with 90% of cases being sporadic. Sarcoidosis is an inflammatory disease affecting multiple organs, with neurological complications occurring in 5-10% of patients. Only isolated cases of this extremely rare combination of the two diseases have been reported.

Methods: We present the case of a 45-year-old man diagnosed with ALS after a 2-year history of progressive upper limb weakness who was incidentally found to be affected by thoraco-abdominal lymphadenopathy. The biopsy confirmed the co-presence of sarcoidosis. We also make a systematic review of the literature of this rare combination.

Results: The patient showed stabilization of the neurological condition and the pneumological disease after administration of immunosuppressive treatment.

Conclusion: Our case report and literature review highlight peculiar clinical characteristics of this extremely rare combination of diseases, deepening the understanding of this peculiar phenotype.

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肌萎缩性侧索硬化症和结节病的共同发病：1例报告和文献的系统回顾。

背景：肌萎缩侧索硬化症（ALS）是一种影响运动神经元的神经退行性疾病，90%的病例是散发性的。结节病是一种影响多器官的炎症性疾病，5-10%的患者出现神经系统并发症。这两种疾病的这种极为罕见的结合仅报告了个别病例。方法：我们提出的情况下，45岁的男子诊断为ALS后，2年的进行性上肢无力的历史，谁是偶然发现的胸腹淋巴结病的影响。活检证实结节病同时存在。我们还对这一罕见组合的文献进行了系统回顾。结果：经免疫抑制治疗后，患者神经系统及肺部疾病均稳定。结论：我们的病例报告和文献回顾突出了这种极其罕见的疾病组合的特殊临床特征，加深了对这种特殊表型的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.