{"title":"Coulometric titration of sulfanilamide as a standard for diazotization titration and nitrite determination.","authors":"Toshiaki Asakai","doi":"10.1007/s00216-025-05971-4","DOIUrl":null,"url":null,"abstract":"<p><p>Sulfanilamide and nitrite have been standardized to each other by diazotization titration; however, no literature was found on determination methods for either material on an absolute basis. In the present study, coulometric titration with electrogenerated bromine was first used to determine sulfanilamide. Coulometric titration provides absolute assays of the amount of substances, based on Faraday's laws of electrolysis, and also has a high degree of accuracy compared to other instrumental methods. Nitrite was assayed by diazotization titration based on the coulometrically determined sulfanilamide. This idea provides a new methodology for the absolute determination of the purity of basic chemicals whose purity could previously only be assessed in relative terms.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"4291-4298"},"PeriodicalIF":3.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00216-025-05971-4","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/19 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Sulfanilamide and nitrite have been standardized to each other by diazotization titration; however, no literature was found on determination methods for either material on an absolute basis. In the present study, coulometric titration with electrogenerated bromine was first used to determine sulfanilamide. Coulometric titration provides absolute assays of the amount of substances, based on Faraday's laws of electrolysis, and also has a high degree of accuracy compared to other instrumental methods. Nitrite was assayed by diazotization titration based on the coulometrically determined sulfanilamide. This idea provides a new methodology for the absolute determination of the purity of basic chemicals whose purity could previously only be assessed in relative terms.
期刊介绍：
Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
