S S Kataev, O N Dvorskaya, A V Vasilenko, E A Krylova
{"title":"[Development of conditions for determination of imidazole derivatives in the blood using chromatography-mass spectrometry].","authors":"S S Kataev, O N Dvorskaya, A V Vasilenko, E A Krylova","doi":"10.17116/sudmed20256803132","DOIUrl":null,"url":null,"abstract":"<p><p>The problem of clonidine, moxonidine, tizanidine determination in forensic studies of biological objects remains due to low therapeutic and toxic concentrations in biological material, that creates certain difficulties in detecting the use of these substances. The study objective is to develop chromato-mass-spectrometry conditions for imidazole derivatives determination in the blood for purposes of forensic chemical and chemical toxicological analysis. The conditions for reliable clonidine, moxonidine, tizanidine identification in the blood using solid-phase extraction and gas chromatography with mass-spectrometry detection are selected. Gas chromatographic and mass spectrometric characteristics of clonidine, moxonidine, tizanidine derivatives which can be used for the purposes of forensic chemical and chemical toxicological analysis were studied.</p>","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":"68 3","pages":"32-37"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sudebno-Meditsinskaya Ekspertisa","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/sudmed20256803132","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The problem of clonidine, moxonidine, tizanidine determination in forensic studies of biological objects remains due to low therapeutic and toxic concentrations in biological material, that creates certain difficulties in detecting the use of these substances. The study objective is to develop chromato-mass-spectrometry conditions for imidazole derivatives determination in the blood for purposes of forensic chemical and chemical toxicological analysis. The conditions for reliable clonidine, moxonidine, tizanidine identification in the blood using solid-phase extraction and gas chromatography with mass-spectrometry detection are selected. Gas chromatographic and mass spectrometric characteristics of clonidine, moxonidine, tizanidine derivatives which can be used for the purposes of forensic chemical and chemical toxicological analysis were studied.
期刊介绍：
The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
