Ophicalcitum-Inspired Microspheres as a Topical Hemostatic Agent.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-06-18 DOI:10.1021/acsabm.5c00925
Yang Liu, Fen Wan, Ruoyu Ba, Yimin Han, Ting Geng, Beihua Bao, Weifeng Yao, Wei-Wei Xiong, Li Zhang, Fang-Fang Cheng
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引用次数: 0

Abstract

Ophicalcitum, as an oral mineral in traditional Chinese medicine, has a long history of therapeutic use in hemostasis, and its main component is calcium carbonate, which has good biosafety, excellent structural properties, and low cost. Inspired by it, calcium carbonate microspheres with different particle sizes were synthesized using ethylene glycol and ultrapure water as solvents. Furthermore, luteolin was loaded onto calcium carbonate microspheres to prepare multifunctional hemostatic materials with healing-promoting effects. Experimental results have shown that calcium carbonate microspheres had excellent hemostatic properties without hemolytic, cytotoxic, and metabolic toxic effects and their hemostatic properties were independent of particle sizes. In addition, luteolin loaded on calcium carbonate microspheres promoted skin healing, indicating that these calcium carbonate microspheres were potential hemostatic materials.

眼钙微球作为局部止血剂。
胡钙素作为一种中药口服矿物质,在止血治疗方面有着悠久的历史,其主要成分为碳酸钙,具有良好的生物安全性、优异的结构性能、低廉的成本。受其启发,以乙二醇和超纯水为溶剂,合成了不同粒径的碳酸钙微球。将木犀草素负载在碳酸钙微球上制备具有促愈合作用的多功能止血材料。实验结果表明,碳酸钙微球具有优异的止血性能,无溶血、细胞毒性和代谢毒性作用,其止血性能与颗粒大小无关。此外,木犀草素负载的碳酸钙微球促进皮肤愈合,表明这些碳酸钙微球是潜在的止血材料。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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