The primary cilium as a gatekeeper of FGFR2 function.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-06-12 DOI:10.1083/jcb.202505022

Raman Kaushik,Raj K Ladher

引用次数: 0

Abstract

In this issue, Nita et al. (https://doi.org/10.1083/jcb.202311030) show that the primary cilium regulates FGFR2 signalling through spatial compartmentalization, enabling selective downstream activation. Disruption of ciliary localization in disease-linked FGFR2 variants highlights the role of the cilium as a signalling gatekeeper in development and disease.

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初级纤毛作为FGFR2功能的守门人。

在本期杂志中，Nita等人（https://doi.org/10.1083/jcb.202311030）表明，初级纤毛通过空间区隔化调节FGFR2信号传导，从而实现选择性下游激活。疾病相关FGFR2变异中纤毛定位的破坏突出了纤毛在发育和疾病中作为信号看门人的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.