The proteome of the late Middle Pleistocene Harbin individual

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-06-18 DOI:10.1126/science.adu9677

Qiaomei Fu, Fan Bai, Huiyun Rao, Shaokun Chen, Yannan Ji, Aoran Liu, E. Andrew Bennett, Feng Liu, Qiang Ji

引用次数: 0

Abstract

Denisovans are a hominin group primarily known through genomes or proteins, but the precise morphological features of Denisovans remain elusive due to the fragmentary nature of discovered fossils. Here we report ninety-five endogenous proteins retrieved from a nearly complete cranium from Harbin, China, dating to at least 146,000 years ago and previous assigned to a new species, Homo longi . This individual has three Denisovan derived amino acid variants and clusters with Denisova 3, suggesting the Harbin individual belongs to a Denisovan population. This study fills the gap between morphological and molecular evidence, enhancing our understanding of Denisovans’ spatiotemporal dispersal and evolutionary history.

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中更新世晚期哈尔滨个体的蛋白质组

丹尼索瓦人是一个主要通过基因组或蛋白质来了解的古人类群体，但由于发现的化石的碎片性，丹尼索瓦人的精确形态特征仍然难以捉摸。在这里，我们报告了从中国哈尔滨一个几乎完整的头盖骨中提取的95种内源性蛋白质，该头盖骨可追溯到至少14.6万年前，之前被分配给一个新的物种——隆基人。该个体有3个丹尼索瓦人衍生的氨基酸变体，并与丹尼索瓦人3有相似的聚类，表明哈尔滨个体属于丹尼索瓦人。该研究填补了形态与分子证据之间的空白，增强了我们对丹尼索瓦人时空分布和进化历史的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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