Ovarian teratomas causing anti-N-methyl-D-aspartate receptor encephalitis: a case series from west China.

IF 1.5 4区医学 Q4 ONCOLOGY

Translational cancer research Pub Date : 2025-05-30 Epub Date: 2025-05-13 DOI:10.21037/tcr-24-2126

Jiaxin Gu, Xiumei Xu, Qian Chen, Min Feng, Ruiqi Duan

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引用次数: 0

Abstract

Background: The incidence of ovarian teratomas (OT) causing anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is low, and pathological studies of related cases are limited. This study aimed to analyze the clinical data of such patients and to investigate the expression of N-methyl-D-aspartate receptor (NMDAR) and lymphocytes in teratoma tissues to initially investigate the pathogenesis of the disease.

Methods: Clinical data were collected and analyzed. Immunohistochemistry was applied to detect the expression of NMDAR subunits and T/B lymphocytes in 46 patients, including 8 OT patients with encephalitis and 38 regular OT patients. Immunohistochemical expression of NMDARs and T/B lymphocytes in OT tissues in patients with or without anti-NMDARE.

Results: Teratomas causing encephalitis mostly occur in young women. The degree of positive expression of NMDAR, CD4 and CD20 in the encephalitis group differed statistically from the control group (P<0.05). Although there was no linear relationship between the CD4/CD20 expression and the NMDAR expression, clusters of lymphocytes were observed clearly around the squamous epithelium positive for NMDAR expression only in the encephalitis group.

Conclusions: OT leading to encephalitis seems to be associated with high expression of NMDARs in the squamous epithelium of the tissue, where clusters of lymphocytes infiltration is also a unique pathological feature. This is the first multi-case group study about OTs causing anti-NMDARE in southwestern China.

查看原文本刊更多论文

卵巢畸胎瘤致抗n -甲基- d -天冬氨酸受体脑炎：中国西部病例系列。

背景：卵巢畸胎瘤（OT）引起抗n -甲基- d -天冬氨酸受体脑炎（anti-NMDARE）的发病率较低，相关病例的病理研究有限。本研究旨在分析这类患者的临床资料，研究n -甲基- d -天冬氨酸受体（NMDAR）和淋巴细胞在畸胎瘤组织中的表达情况，初步探讨该病的发病机制。方法：收集临床资料并进行分析。应用免疫组化技术检测46例脑炎OT患者NMDAR亚基及T/B淋巴细胞的表达，其中脑炎OT患者8例，正常OT患者38例。抗nmdare或非抗nmdare患者OT组织中NMDARs和T/B淋巴细胞的免疫组化表达。结果：畸胎瘤所致脑炎多见于年轻女性。脑炎组NMDAR、CD4和CD20的阳性表达程度与对照组有统计学差异(p)结论：OT导致脑炎可能与组织鳞状上皮NMDAR的高表达有关，鳞状上皮细胞的聚集性浸润也是其独特的病理特征。这是中国西南地区首个关于OTs引起抗nmdare的多病例组研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational cancer research ONCOLOGY-

CiteScore

2.10

自引率

0.00%

发文量

252

期刊介绍： Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.