Malignant transformation of pituitary adenoma to carcinosarcoma: illustrative case.

Lin Shaoyong, Huanxiang Huang, Mingyue Wang, Jun Li, Yuhui Chen, Shousen Wang
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引用次数: 0

Abstract

Background: Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs).

Observations: The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy.

Lessons: Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients. Combined therapeutic strategies may be considered for radiation-induced sarcomas, and comprehensive molecular pathological studies of radiation-induced tumors are imperative for advancing understanding and management. https://thejns.org/doi/10.3171/CASE24765.

垂体腺瘤向癌肉瘤的恶性转化:说明性病例。
背景:垂体腺瘤(PAs)放射治疗后发生癌变是一种罕见的并发症。观察:作者报告了他们认为的第一例良性无功能PA在手术和放疗后发展为癌肉瘤的病例。经验教训:PAs的放疗应考虑继发性颅内肿瘤的风险,建议对治疗后的患者进行长期随访。放射性肉瘤可以考虑综合治疗策略,对放射性肿瘤进行全面的分子病理学研究对于提高认识和治疗是必要的。https://thejns.org/doi/10.3171/CASE24765。
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