Lin Shaoyong, Huanxiang Huang, Mingyue Wang, Jun Li, Yuhui Chen, Shousen Wang
{"title":"Malignant transformation of pituitary adenoma to carcinosarcoma: illustrative case.","authors":"Lin Shaoyong, Huanxiang Huang, Mingyue Wang, Jun Li, Yuhui Chen, Shousen Wang","doi":"10.3171/CASE24765","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs).</p><p><strong>Observations: </strong>The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy.</p><p><strong>Lessons: </strong>Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients. Combined therapeutic strategies may be considered for radiation-induced sarcomas, and comprehensive molecular pathological studies of radiation-induced tumors are imperative for advancing understanding and management. https://thejns.org/doi/10.3171/CASE24765.</p>","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 24","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171103/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neurosurgery. Case lessons","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3171/CASE24765","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs).
Observations: The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy.
Lessons: Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients. Combined therapeutic strategies may be considered for radiation-induced sarcomas, and comprehensive molecular pathological studies of radiation-induced tumors are imperative for advancing understanding and management. https://thejns.org/doi/10.3171/CASE24765.