Pioneer transcription factor two-pronged way to promote endothelial cell differentiation

Abstract

Single-cell analyses defined the mechanisms by which the pioneer transcription factor ETV2 drives endothelial cell specification from mesodermal progenitors in vitro. ETV2 interaction with a transcription factor (GABPA) promoted endothelial cells differentiation, and ETV2 interaction with a repressor (REST) inhibited differentiation to alternative cell types.