Ocular Mucosal Pemphigoid: Diagnosis, Clinic and Therapy.

Abstract

Ocular mucosal pemphigoid is a rare, chronically progressive autoimmune disease of the ocular surface. It belongs to a group of diseases whose common clinical correlate is the disruption of cohesion at the basement membrane. Recurrent inflammation with progressive fibrosis of the conjunctiva and damage to limbal stem cells are characteristic. If the course remains uncontrolled, severe morphological and functional damage can occur, up to blindness. Therefore, the critical perception of initially subtle findings and early diagnostic are of great importance. The aim of immune modulative therapy is to control the underlying inflammation and prevent the progression of fibrosis, in order to avoid serious complications.