{"title":"Cardiac and systemic inflammation in cardiogenic shock.","authors":"Guillaume Théry, Nadia Aissaoui, Olfa Hamzaoui","doi":"10.1097/MCC.0000000000001286","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>The understanding of cardiogenic shock (CS) has significantly evolved over the past decades. Initially regarded as a purely mechanistic syndrome, CS is now recognized as a multifaceted condition that incorporates a complex interplay of hemodynamic compromise and a cascading inflammatory response. This review aims to describing cardiac and systemic inflammation involvement in cardiogenic shock.</p><p><strong>Recent findings: </strong>Defining subphenotypes among CS patients is mandatory as it is no longer considered as a homogeneous entity. Accordingly, including inflammatory biomarkers in a risk-stratification approach and identifying populations who will predictably respond to tailored therapies is a major concern.</p><p><strong>Summary: </strong>In this review, we propose a narrative review on cardiac and systemic inflammation occurring in CS, current research on inflammatory biomarkers and their implications in risk-stratification, and upcoming trials on therapies targeting inflammation.</p>","PeriodicalId":10851,"journal":{"name":"Current Opinion in Critical Care","volume":" ","pages":"437-443"},"PeriodicalIF":3.4000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Critical Care","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCC.0000000000001286","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: The understanding of cardiogenic shock (CS) has significantly evolved over the past decades. Initially regarded as a purely mechanistic syndrome, CS is now recognized as a multifaceted condition that incorporates a complex interplay of hemodynamic compromise and a cascading inflammatory response. This review aims to describing cardiac and systemic inflammation involvement in cardiogenic shock.
Recent findings: Defining subphenotypes among CS patients is mandatory as it is no longer considered as a homogeneous entity. Accordingly, including inflammatory biomarkers in a risk-stratification approach and identifying populations who will predictably respond to tailored therapies is a major concern.
Summary: In this review, we propose a narrative review on cardiac and systemic inflammation occurring in CS, current research on inflammatory biomarkers and their implications in risk-stratification, and upcoming trials on therapies targeting inflammation.
期刊介绍：
Current Opinion in Critical Care delivers a broad-based perspective on the most recent and most exciting developments in critical care from across the world. Published bimonthly and featuring thirteen key topics – including the respiratory system, neuroscience, trauma and infectious diseases – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.
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