Oral administration of undenatured type II collagen significantly inhibits arthritis-associated pain signal in a mouse model of collagen antibody-induced arthritis and meniscus removal

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2025-06-12 DOI:10.1016/j.jphs.2025.06.001

Ibuki Yasuda , Mao Kaneki , Chiharu Ohira , Mana Ichikawa , Eiji Iwazaki , Hirohito Tsuruwaka , Tomoki Fukuyama

引用次数: 0

Abstract

Osteoarthritis (OA) is joint pain caused by persistent low-grade inflammation, and is characterized by bone remodeling, synovitis, and articular cartilage degeneration. This study focused on undenatured type II collagen (UC-II®) and examined its influence on OA-associated pain. The increased Ca²⁺ influx to typical nociceptive receptors TRPA1 and TRPV1 in the peripheral neurons of dorsal root ganglia was significantly inhibited by UC-II® treatment and similar inhibitory patterns were confirmed in vivo pain behavior tests in a mouse model of arthritis. Our findings suggest the effectiveness of UC-II® on OA-associated pain.

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在胶原抗体诱导的关节炎和半月板切除小鼠模型中，口服未变性的II型胶原可显著抑制关节炎相关的疼痛信号

骨关节炎（OA）是由持续的低度炎症引起的关节疼痛，以骨重塑、滑膜炎和关节软骨变性为特征。本研究聚焦于未变性II型胶原蛋白（UC-II®），并研究其对oa相关疼痛的影响。UC-II®治疗显著抑制了背根神经节外周神经元中典型伤害性受体TRPA1和TRPV1的Ca2+内流增加，并且在小鼠关节炎模型的体内疼痛行为测试中证实了类似的抑制模式。我们的研究结果表明UC-II®对oa相关疼痛的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.