H3K27me3 expands the epigenetic control of piRNA transcription

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-06-17 DOI:10.1038/s41594-025-01572-y

Arantxa M. L. Rojas, Germano Cecere

引用次数: 0

Abstract

Constitutive heterochromatin can promote piRNA transcription, a crucial step in genome defense. Two studies now show that piRNA transcription in Drosophila is regulated by the dual histone marks H3K27me3 and H3K9me3, and piRNA transcription in Caenorhabditis elegans is enhanced by H3K27me3, gene clustering and phase separation.

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H3K27me3扩展了piRNA转录的表观遗传控制

组成型异染色质可以促进piRNA转录，这是基因组防御的关键步骤。目前有两项研究表明，果蝇的piRNA转录受H3K27me3和H3K9me3双组蛋白标记调控，秀丽隐杆线虫的piRNA转录受H3K27me3、基因聚类和相分离的促进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.