The sulfenylation of imidazopyridines with sulfinic acids mediated by DTBP/HCl

Abstract

A direct sulfenylation reaction of imidazopyridines with sulfinic acid mediated by di-tert-butylperoxide (DTBP) and hydrochloric acid was developed leading to the introduction of CS bonds into the imidazo[1,2-a]pyridine skeleton. The reaction proceeded under transition-metal-free conditions with good functional group tolerance and moderate to excellent yields.