Base-promoted Annulations of α-Halohydroxamates with 2-(Substituted(tosyl)methyl)phenols for the Synthesis of 1,4-Benzoxazepine Derivatives

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-06-13 DOI:10.1016/j.tet.2025.134777

Chenbo Guo , Yi Li , Qiqi Zhang, Wanyu Yan, Jing Zou, Gang Wang, Zhao-Lin He

引用次数: 0

Abstract

A base promoted annulation reaction of α-halohydroxamates with 2-(substituted(tosyl)methyl)phenols was developed. The synthetic protocol provided an efficient route to 1,4-benzoxazepine derivatives in moderate to excellent yields under mild condition, exhibiting good functional group tolerance.

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α-卤代羟基酸酯与2-（取代（甲酰基）甲基）酚的碱基促进环化合成1,4-苯并恶氮平衍生物

研究了α-卤代羟基酸酯与2-（取代甲基）苯酚的碱促环化反应。该合成方案为在温和条件下以中等至优异收率合成1,4-苯并恶西平衍生物提供了一条有效途径，并具有良好的官能团耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.