A Review of Research from 2012 to 2024 on Pyrazole-based Anticancer Agents with SAR Study.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-06-10 DOI:10.2174/0115680266370083250530180225

Deepali Wanode, Deweshri Nandurkar, Megha Ambatkar, Nilesh Rarokar, Pramod Khedekar

引用次数: 0

Abstract

The field of cancer research has witnessed a surge in the exploration of novel therapeutic agents, with pyrazole derivatives emerging as promising candidates in the quest for effective anticancer treatments. This comprehensive review provides an in-depth analysis of the research landscape surrounding pyrazole derivatives as potential anticancer agents over the period from 2012 to 2024. Many synthetic pyrazole derivatives have been approved by the FDA and used as chemotherapeutic medicines, and some are under clinical trials, also reported in this article. The review aims to serve as a valuable resource for researchers, guiding future investigations and fostering the development of innovative pyrazole-based anticancer therapeutics.

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2012 - 2024年吡唑类抗癌药物SAR研究综述

癌症研究领域见证了对新型治疗药物探索的激增，吡唑衍生物在寻求有效的抗癌治疗中成为有希望的候选者。本综述对吡唑衍生物作为潜在抗癌药物的研究前景进行了深入分析，从2012年到2024年。许多合成吡唑衍生物已被FDA批准并用作化疗药物，其中一些正在进行临床试验，本文也有报道。该综述旨在为研究人员提供宝贵的资源，指导未来的研究和促进创新的吡唑类抗癌疗法的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.