Synthesis and Structural Insights into 1,4-Bis(phenylsulfonyl)-1H-pyrazol-5-amine Derivatives via a One-Pot Domino Reaction

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-06-14 DOI:10.1002/slct.202501021

Lingyun Li, Li Hu, Zhengyu Zhang

引用次数: 0

Abstract

A one-pot, efficient domino reaction was developed for the synthesis of 1,4-bis(phenylsulfonyl)-1H-pyrazol-5-amine derivatives, using tetrabutylammonium iodide (TBAI) as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant. The reaction, conducted at room temperature, successfully formed both C─S and C─N bonds between benzoylacetonitrile and phenylsulfonhydrazine. This method offers several advantages, including mild reaction conditions, a wide substrate scope, high yields, and simplicity. The synthesized compounds were characterized by nuclear magnetic resonance (NMR) spectroscopy.

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一锅多米诺反应合成1,4-双（苯基磺酰基）- 1h -吡唑-5-胺衍生物及其结构研究

以四丁基碘化铵（TBAI）为催化剂，过氧化叔丁基（thbhp）为氧化剂，采用一锅高效的多米诺反应合成了1,4-二（苯基磺酰基）- 1h -吡唑-5胺衍生物。在室温下，苯甲酰乙腈和苯磺肼成功地形成了C─S键和C─N键。该方法具有反应条件温和、底物范围广、产率高、操作简单等优点。合成的化合物通过核磁共振（NMR）光谱进行了表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.