Using RNA therapeutics to promote healthy aging.

IF 17 Q1 CELL BIOLOGY

Nature aging Pub Date : 2025-06-01 Epub Date: 2025-06-11 DOI:10.1038/s43587-025-00895-1

Shuying Chen, Qian Chen, Xinru You, Zhuoming Zhou, Na Kong, Fabrisia Ambrosio, Yihai Cao, Reza Abdi, Wei Tao

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Abstract

Aging is characterized by a gradual decline of cellular and physiological functions over time and an increased risk of different diseases. RNA therapeutics constitute an emerging approach to target the molecular mechanisms of aging and age-related diseases via rational design and have several advantages over traditional drug therapies, including high specificity, low toxicity and the potential for rapid development and production. Here, we discuss the latest developments in RNA therapeutics designed to promote healthy aging, including RNA activation, messenger RNA therapy, RNA interference, antisense oligonucleotides, aptamers and CRISPR-Cas-mediated RNA editing. We also review the latest preclinical and clinical studies of RNA technology for treating age-related diseases, including neurodegenerative, cardiovascular and musculoskeletal diseases. Finally, we discuss the challenges of RNA technology aimed at supporting healthy aging. We anticipate that the fusion of RNA therapeutics and aging biology will have an important effect on the development of new medicines and maximization of their efficacy.

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利用RNA疗法促进健康衰老。

衰老的特点是细胞和生理功能随着时间的推移逐渐下降，患不同疾病的风险增加。RNA疗法是一种通过合理设计来针对衰老和年龄相关疾病的分子机制的新兴方法，与传统药物疗法相比，RNA疗法具有一些优势，包括高特异性、低毒性和快速开发和生产的潜力。在这里，我们讨论了旨在促进健康衰老的RNA治疗的最新进展，包括RNA激活，信使RNA治疗，RNA干扰，反义寡核苷酸，适体和crispr - cas介导的RNA编辑。我们还回顾了RNA技术治疗年龄相关疾病的最新临床前和临床研究，包括神经退行性疾病、心血管疾病和肌肉骨骼疾病。最后，我们讨论了RNA技术在支持健康衰老方面所面临的挑战。我们预计RNA治疗学与衰老生物学的融合将对新药的开发和疗效最大化产生重要影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature aging

CiteScore

14.70

自引率

0.00%

发文量