Emerging Capabilities of Nonclassical Noncovalent Interactions and Asymmetric Catalysis in Stereoselective Glycosylations and Carbohydrate Functionalizations

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2025-06-12 DOI:10.1021/acs.accounts.5c00289

Amal Tom Sebastian, Charles C. J. Loh

引用次数: 0

Abstract

Deriving inspiration from frontier catalytic paradigms has emerged as a major force to tackle long-standing stereoselectivity issues in carbohydrate synthesis. In particular, there is a strong momentum in the harnessing of nonclassical σ-hole based noncovalent interactions (NCIs) in chemical glycosylations and the use of asymmetric catalysis to surmount the formidable site-selectivity challenge in the functionalization of carbohydrate polyols.

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立体选择性糖基化和碳水化合物功能化中非经典非共价相互作用和不对称催化的新能力

从前沿催化范式中获得灵感已经成为解决碳水化合物合成中长期存在的立体选择性问题的主要力量。特别是，在化学糖基化过程中利用非经典的σ-空穴非共价相互作用（nci）和利用不对称催化来克服碳水化合物多元醇功能化过程中令人难以克服的位点选择性挑战方面，有很强的发展势头。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.