Towards total synthesis of lophotoxin and congeners: Recent progress and transannulation strategy

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-06-09 DOI:10.1016/j.tet.2025.134776

Xi Wang, Yu Peng, Wei-Dong Z. Li

引用次数: 0

Abstract

Lophotoxin is a structurally unique and prominent marine furanocembranolide natural product. Despite numerous attempts since its discovery in 1981, the total synthesis of lophotoxin has not yet been achieved to date. This review summarized synthetic efforts and recent progress since 1984 in the synthesis of the lophotoxin skeleton and its analogues. Moreover, strategic perspectives on a range of transannulation approaches for furanocembranoid synthesis were also highlighted herein.

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lophotoxin及其同系物的全合成：最新进展和跨环策略

Lophotoxin是一种结构独特、功能突出的海洋呋喃壬烷内酯天然产物。尽管自1981年发现lophotoxin以来进行了多次尝试，但迄今为止尚未实现lophotoxin的完全合成。本文综述了1984年以来lophotoxin骨架及其类似物的合成情况和最新进展。此外，本文还强调了一系列跨环法合成呋喃类膜的战略观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.